Autonomous Cortisol Secretion and High Rates of Atrial Fibrillation

In a retrospective study of patients with adrenal incidentalomas and autonomous cortisol secretion (ACS; also known as subclinical Cushing's syndrome), rates of atrial fibrillation (AF) were higher when compared with nonsecreting adenomas and the general population (8.5, 3.1, and 1.7 percent, respectively). At the completion of the study (median follow-up of 7.7 years), the AF rate remained higher in the ACS group: 20 versus 12 percent in the nonsecreting group. Given these high rates, patients with ACS should be monitored for AF.

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