Laryngial Pleomorphic Adenoma with Challenging Clinical Presentation.
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Introduction
Pleomorphic adenomas (PA) also called benign mixed tumors are most common tumors of salivary glands. They occur mainly in major salivary glands but may also arise from minor salivary glands of upper respiratory and alimentary tract. Histologically, these tumors are encapsulated and consist of benign epithelial and /or myoepithelial and stromal elements. About 80% of PA arise in the parotid gland, 10% in the submandibular gland, and 10% in the minor salivary glands of the oral cavity, paranasal sinuses, and upper respiratory and alimentary tract. Those tumors have the capacity to transform into malignancy when they stay long without treatment.
Pleomorphic adenoma arising from the larynx is very rare, the literature report less than 30 cases. PA may occur at any age, but mainly they affect patients in the 4-6 decades with a male to female ration 2:1. When the larynx is involved, the most common site of involvement is the epiglottis and subglottis in some cases [5].