Molecularly Targeted therapy
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Targeted therapy or molecularly targeted therapy is one of the major modalities of medical treatment (pharmacotherapy) for cancer, others being hormonal therapy and cytotoxic chemotherapy. As a form of molecular medicine, targeted therapy blocks the growth of cancer cells by interfering with specific targeted molecules needed for carcinogenesis and tumor growth, rather than by simply interfering with all rapidly dividing cells (e.g. with traditional chemotherapy). Because most agents for targeted therapy are biopharmaceuticals, the term biologic therapy is sometimes synonymous with targeted therapy when used in the context of cancer therapy (and thus distinguished from chemotherapy, that is, cytotoxic therapy). However, the modalities can be combined; antibody-drug conjugates combine biologic and cytotoxic mechanisms into one targeted therapy.
Another form of targeted therapy involves use of nano-engineered enzymes to bind to a tumor cell such that the body's natural cell degradation process can digest the cell, effectively eliminating it from the body. Targeted cancer therapies are expected to be more effective than older forms of treatments and less harmful to normal cells. Many targeted therapies are examples of immunotherapy (using immune mechanisms for therapeutic goals) developed by the field of cancer immunology. They are one type of biological response modifiers. The most successful targeted therapies are chemical entities that target or preferentially target a protein or enzyme that carries a mutation or other genetic alteration that is specific to cancer cells and not found in normal host tissue.
Medical Physicists will contribute to maintaining and improving the quality, safety and cost-effectiveness of healthcare services through patient-oriented activities requiring expert action, involvement or advice regarding the specification, selection, acceptance testing, commissioning, quality assurance/control and optimised clinical use of medical devices and regarding patient risks and protection from associated physical agents (e.g. x-rays, electromagnetic fields, laser light, radionuclides) including the prevention of unintended or accidental exposures; all activities will be based on current best evidence or own scientific research when the available evidence is not sufficient. Medical physics is also called biomedical physics, medical biophysics or applied physics in medicine is, generally speaking, the application of physics concepts, theories and methods to medicine or healthcare. Medical physics departments may be found in hospitals or universities. Medical physics has a much wider scope and may include research in any applications of physics to medicine from the study of biomolecular structure to microscopy and nanomedicine. Insights in Medical Physics is an open access scientifc journal which publishes peer reviewed articles in the area of medical physics. The journal publish articles with theoretical and experimental contributions for publication covering all dimensions of medical physics such as application of radiation physics with relation to radiation therapies, nuclear medicine related physics applications, medical imaging, signal processing and signal output analysis for medical devices, application of physics in biomedical devise development, computer aided image analysis etc. Articles are welcome in the mentioned discipline along with other associated areas of the subject. The Journal is using Editor Manager System for easy online tracking and managing of the manuscript processing.
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Eliza Miller
Managing Editor
Journal of Medical Physics and Applied Sciences
E-mail: medicalsci@medicinaljournals.com